Cannabis suppositories are often considered a sensitive topic. While they are an ancient form of medicine, many people still get squeamish when discussing inserting anything into the rectum or vagina. It is a personal subject—not exactly dinner-table conversation, and certainly not something everyone feels comfortable asking about at a busy dispensary counter.
However, suppositories are a highly effective form of marijuana medicine that shouldn’t be ignored simply because of how they are administered. They offer targeted relief for deep pelvic issues that other methods often miss. The best part? You don’t have to awkwardly ask for them at a store—you can easily make them yourself at home using your own harvest.
Cannabis suppositories are technically classified as topicals, even though they are inserted internally. They are small, bullet-shaped capsules infused with cannabis oil that have a texture similar to a firm balm. Once inserted into the vagina or rectum, the suppository melts, allowing the cannabinoids to disperse and be absorbed by the local tissue.
While the delivery method might seem modern, “butt drugs” have been around for thousands of years. The term “suppository” was coined in 1763, but the practice appears in ancient Hebrew Scriptures and Egyptian papyruses.
Today, medical cannabis use is multifaceted. No one uses a suppository to “get high” (more on that later). Instead, they are a unique, powerful option for people seeking specific, localized relief without the psychoactive side effects associated with smoking or edibles.
Suppositories work by interacting with the endocannabinoid system (ECS) receptors and nerve endings, which are incredibly abundant in the pelvic region.
Your pelvic area—including the anus, vagina, cervix, and ovaries—is dense with ECS receptors. This makes suppositories a promising treatment option for localized conditions like endometriosis, menstrual cramping, and even colon issues. The colon contains both CB1 and CB2 receptors, and prostate tissue is also rich in cannabinoid receptors.
Since cannabinoids like THC and CBD are fat-soluble, suppositories use a carrier base to ensure absorption. Common carriers include coconut oil, avocado oil, or cocoa butter.
The short answer is: Likely not.
Cannabis suppositories typically deliver localized relief rather than systemic intoxication. Because the cannabinoids are absorbed through the vaginal wall or rectal tissue rather than bypassing the liver (like an edible) or entering the lungs (like smoke), most users do not experience a “head high.”
However, it is theoretically possible to feel psychoactive effects if the suppository contains a massive dose of THC. As with all cannabis products, “start low and go slow” applies here.
There is a common myth that rectally delivered THC is 2.5x more bioavailable than oral consumption. This data is often misleading; the study citing this figure used a chemically modified version of THC (D9-THC-HS), not the natural THC found in your garden.
Current research suggests that standard THC suppositories provide excellent local bioavailability (acting like a powerful internal topical) rather than systemic bioavailability (entering the bloodstream to reach the brain). This is why they are so effective for pain without the high.
The main difference between rectal and vaginal use comes down to anatomy and the specific issue being treated. The medicine itself is often the same, but the application differs.
Yes, you can make these at home! In fact, making your own is often better because you can control the ingredients and the strain.
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